Located in the peripheral cabinet, this glider is designed to accept a standard sized tower CPU configuration (up to 24" in height). In the single door, 48" wide Professional model (or if you've chosen the double door CEO model and have two towers) you'll find that wiring and shelving are already in place to site a similar sized tower below desk (at left) in the main compartment. Using a Desk-top style CPU? Not a problem. There's plenty of room. Locate it on the desk-top if you prefer, but might we suggest the spacious printer compartment? Wiring is in place, and your printer will easily fit right on top of the desk-top CPU.